Greek PM presses for deal on loan
















ATHENS, Greece (AP) — Greece has reacted with dismay to the European Union‘s failure to agree to release vital rescue loan funds for the debt-ridden country, with the prime minister warning it was not just Greece’s future that hangs in the balance.


The delay prolongs uncertainty over the future of Greece, which faces a messy default that would threaten the entire euro currency used by 17 EU nations.













Prime Minister Antonis Samaras stressed that Greece has done what its creditors from the EU and International Monetary Fund required. “Our partners, along with the IMF, also must do what they have committed to doing,” he said.


He said that “it is not just the future of our country, but the stability of the entire eurozone” that depend on the success of negotiations in coming days.


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Microsoft vs. Google trial over patents finishes up
















SEATTLE (Reuters) – A Google expert witness testified on Tuesday that Microsoft will make roughly $ 94 billion in revenue through 2017 from its Xbox game console and Surface tablet that use Google‘s patented wireless technology.


Michael Dansky, an expert for Google‘s Motorola Mobility unit, testified on the last day of a high stakes trial over patents between Microsoft and Google in Seattle. The $ 94 billion figure he cited also includes a wireless adapter that Microsoft no longer sells. It was not clear how far back he was counting past revenues.













Microsoft declined comment on the figure.


The week-long trial in a Seattle federal court examined how much of a royalty Microsoft Corp should pay Google Inc for a license to some of Motorola‘s patents. Google bought Motorola earlier this year for $ 12.5 billion, partly for its library of communications patents.


Motorola had sought up to $ 4 billion a year for its wireless and video patents, while Microsoft argues its rival deserves just over $ 1 million a year.


If U.S. District Judge James Robart decides Google deserves only a small royalty, then its Motorola patents would be a weaker bargaining chip for Google to negotiate licensing deals with rivals.


The rapid rise of smartphones has sparked an explosion of litigation between major players disputing ownership of the underlying technology and the design of handsets.


Apple Inc and Microsoft have been litigating in courts around the world against Google and partners like Samsung Electronics Co Ltd, which use the Android operating system on their mobile devices.


Apple contends that Android is basically a copy of its iOS smartphone software, and Microsoft holds patents that it contends cover a number of Android features.


In return, Motorola and some other Android hardware makers launched countering legal action.


Before trial, Robart said testimony about patent license agreements between Microsoft, Motorola and other tech companies could be disclosed to the public, along with other sensitive financial information.


However, the judge reversed himself this week and said he was bound by appellate precedent to keep that information secret. On Tuesday he cleared the courtroom and heard two hours of testimony in secret.


During the open session, Dansky said Motorola‘s video patents are crucial to Microsoft and other tech companies, and deserve a high royalty.


“You will have a difficult time selling smart phones or tablets,” Dansky said, without Motorola‘s technology.


Robart is not expected to release a ruling for several weeks as both companies must file further legal briefs.


The case in U.S. District Court, Western District of Washington is Microsoft Corp. vs. Motorola Inc., 10-cv-1823.


(Reporting by Lisa Dembiczak; Writing by Dan Levine; Editing by Richard Pullin)


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J.R.R. Tolkien estate sues Warner Bros. over gambling, games
















LOS ANGELES (Reuters) – The estate of “The Lord of the Rings” author J.R.R. Tolkien and publisher HarperCollins have filed an $ 80 million lawsuit against Warner Bros. studios over the licensing of characters and plots in online and gambling games derived from the films.


The lawsuit, which was filed in U.S. District Court in Los Angeles on Monday, alleges that Warner Bros. and its subsidiary New Line Cinema – which own the merchandising rights to the “Lord of the Rings” and “The Hobbit” brands – infringed on copyrights by licensing to casino slot machines, online gambling, games and downloads.













Tolkien‘s estate accuses Warner Bros., a unit of Time Warner Inc., of “infringing conduct.”


“Not only does the production of gambling games patently exceed the scope of defendants’ rights, but this infringing conduct has outraged Tolkien’s devoted fan base, causing irreparable harm to Tolkien’s legacy and reputation and the valuable goodwill generated by his works,” the lawsuit stated.


The suit claimed Warner Bros. earned millions of dollars from legal merchandise licensing revenue related to “The Lord of the Rings” trilogy of films, which have grossed nearly $ 3 billion at the global box office.


The estate of the late English author and HarperCollins, a division of News Corp., are asking for at least $ 80 million in damages.


Representatives for Warner Bros., Tolkien’s estate and HarperCollins were not immediately available for comment.


The lawsuit comes a week ahead of the New Zealand premiere of “The Hobbit: An Unexpected Journey,” the first of a new trilogy of films returning to Tolkien’s world of elves, goblins and wizards of Middle Earth, based on the “Lord of the Rings” prequel novel “The Hobbit.”


(Reporting By Eric Kelsey; Editing by Piya Sinha-Roy and Mohammad Zargham)


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UN says an end to AIDS in sight
















LONDON (Reuters) – A United Nations report said on Tuesday that eradicating AIDS was in sight, owing to better access to drugs that can both treat and prevent the incurable human immunodeficiency virus (HIV) that causes the disease.


An aim to eventually end the worldwide AIDS epidemic is not “merely visionary” but “entirely feasible”, the report said.













Success in fighting the disease in the past decade has allowed the “foundation to be laid for the eventual end of AIDS” by cutting the death toll and helping stabilise the number of people infected in the pandemic, UNAIDS said its annual report.


Some 34 million people had HIV at the end of 2011.


Worldwide, the number of people newly infected with the disease, which can be transmitted via blood and by semen during sex, is falling. At 2.5 million, the number of new infections in 2011 was 20 percent lower than in 2001.


Deaths from AIDS fell to 1.7 million in 2011, down from a peak of 2.3 million in 2005 and from 1.8 million in 2010.


Sub-Saharan Africa is the most severely affected region with almost one in every 20 adults infected, nearly 25 times the rate in Asia, there are also almost 5 million people with HIV in South, South-East and East Asia combined.


“Although AIDS remains one of the world’s most serious health challenges, global solidarity in the AIDS response during the past decade continues to generate extraordinary health gains,” the report said.


It said this was due to “historic success” in bringing HIV programmes to scale, combined with the emergence of new combination drugs to prevent people from becoming HIV infected and from dying from AIDS.


Since 1995, AIDS drug treatment – known as antiretroviral therapy – has saved 14 million life-years in poorer countries, including 9 million in sub-Saharan Africa, the report said.


Some 8 million people were being treated with AIDS drugs by the end of 2011, a 20-fold increase since 2003. The U.N. has set a target to raise that to 15 million people by 2015.


Scientific studies published in recent years have shown that getting timely treatment to those with HIV can also cut the number of people who become newly infected with the virus.


UNAIDS said the sharpest declines in new HIV infections since 2001 were in the Caribbean and in sub-Saharan Africa – where new infections were down 25 percent in a decade.


Despite this, sub-Saharan Africa still accounted for 71 percent of people newly infected in 2011, underscoring the need to boost HIV prevention efforts in the region, UNAIDS said.


HIV trends are a concern in other regions also, it said.


Since 2001, the number of new HIV infections in the Middle East and North Africa was up more than 35 percent from 27,000 to 37,000, it said, and evidence suggests HIV infections in Eastern Europe and Central Asia began increasing in the late 2000s after being relatively stable for several years.


Medications/Drugs News Headlines – Yahoo! News



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Tel Aviv bus blast shakes Gaza diplomacy

TEL AVIV, Israel (AP) — A bomb struck an Israeli bus near the nation's military headquarters in Tel Aviv on Wednesday, wounding 10 people and complicating major diplomatic efforts to forge a truce between Israel and Gaza's militant Hamas rulers.

The attack came as U.S. Secretary of State Hillary Rodham Clinton shuttled between Jerusalem and the West Bank to help piece together a deal to end Israel's weeklong offensive against Palestinian militants in the Gaza Strip that has killed more than 130 Palestinians. Militant rocket fire into Israel has killed five Israelis. Clinton was due to travel later to Egypt, which is mediating in the crisis.

"What does it say about the future of the (truce) talks? I leave it to (the senior officials), but this doesn't add anything," Yitzhak Aharonovich, Israel's minister of internal security, told Army Radio.

The bus exploded around noon on one of the coastal city's busiest arteries, near the Tel Aviv museum, the district courthouse and across from an entrance to Israel's national defense headquarters.

The bus was completely charred, its side windows blown out and glass scattered on the asphalt. The wounded were evacuated and blood was splattered on the sidewalk.

"We suddenly heard a huge explosion and immediately knew it was a terror attack," said Nir Zano, 35. "I saw someone running in to carry out a woman who was injured."

Aharonovitch said the device was placed inside the bus by a man who then disembarked. The explosion took place while the bus was in movement, he said.

Police set up roadblocks across the city trying to apprehend the attacker.

"We strongly believe that this was a terror attack," said police spokesman Micky Rosenfeld. He said three of the 10 wounded were moderately to seriously hurt.

In Gaza, the Tel Aviv bombing was praised from mosque loudspeakers, while Hamas' television interviewed people praising the attack as a return of militants' trademark tactics.

No group claimed responsibility for the attack, but Hamas spokesman Fawzi Barhoum welcomed it.

"We consider it a natural response to the occupation crimes and the ongoing massacres against civilians in the Gaza Strip," he told The Associated Press.

Israeli Deputy Prime Minister Silvan Shalom, who heard the explosion from his Tel Aviv office, called it "an escalation."

The cease-fire efforts come with thousands of Israeli ground troops massed on the Gaza border, awaiting a possible order to invade.

After meeting with Israeli Prime Minister Benjamin Netanyahu in Jerusalem Tuesday night, Clinton conferred with Palestinian President Mahmoud Abbas in the West Bank on Wednesday morning and was due to travel later to Cairo, which is mediating in the crisis.

The two sides had seemed on the brink of a deal Tuesday following a swirl of diplomatic activity also involving U.N. chief Ban Ki-moon and Egypt's President Mohammed Morsi. But sticking points could not be resolved as talks — and violence — stretched into the night.

Israeli aircraft pounded Gaza with at least 30 strikes overnight, hitting government ministries, smuggling tunnels, a banker's empty villa and a Hamas-linked media office.

Dozens of civilians are among the more than 130 Palestinians killed in a week of fighting. Four Israeli civilians and a soldier have been killed by rocket fire — a toll possibly kept down by a U.S.-funded rocket defense system that has shot down hundreds of Gaza projectiles.

The Tel Aviv bus bombed Wednesday was relatively empty during the explosion, which explains the relatively low number of casualties. The bombing was the first in the coastal city since April 2006, when a Palestinian suicide bomber killed 11 people at a sandwich stand near the city's old central bus station. A bomb left at a bus stand in Jerusalem last year killed one person.

More than 1,000 Israelis were killed during the violent Palestinian uprising in the last decade in bombings and shooting attacks. More than 5,000 Palestinians were killed as well.

___

Associated Press writer Ibrahim Barzak contributed to this report from Gaza City.

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U.S. fiscal impact of great concern to Canada: Canada’s Harper
















TORONTO (Reuters) – Any fiscal problems that would significantly slow the U.S. economy would be of great concern to Canada, Canadian Prime Minister Stephen Harper said on Monday.


The United States needed a credible medium-term fiscal plan, Harper said at a business forum in Ottawa, adding that he was following the U.S. fiscal debate with “great interest.”













(Reporting by Solarina Ho)


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N.Y. police officer says not guilty of plan to cook, eat women
















NEW YORK (Reuters) – A New York City police officer pleaded not guilty on Monday to conspiring to kidnap, torture, cook and eat women.


Gilberto Valle, 28, of Forest Hills, Queens, was charged and arrested in October with conspiring to cross state lines to kidnap the women and with illegally accessing a federal database.













Prosecutors said some of the women were acquaintances of Valle but it was not clear if he knew or had met all of them. Valle, who an official said had no prior criminal record, was not charged with carrying out any of his suspected plans.


At a brief hearing Monday in U.S. District Court in Manhattan, Valle’s attorney, Julia Gatto, told the judge she would again seek to have her client freed on bail after two other judges previously denied her request.


Investigators uncovered a file on Valle’s computer containing the names and pictures of at least 100 women, and the addresses and physical descriptions of some of them, according to the criminal complaint. It said he had undertaken surveillance of some of the women at their places of employment and their homes.


Gatto argues that Valle, a 6-1/2 year NYPD veteran, was all talk and should be released on bail.


The charges carry a maximum sentence of life in prison.


The case is U.S. v. Gilberto Valle, U.S. District Court for the Southern District of New York, No. 12-cr-847.


(Reporting by Basil Katz; Editing by Cynthia Osterman)


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Lindsay Lohan, Liz Taylor and pages of “what ifs” for TV’s “Liz & Dick”
















LOS ANGELES (Reuters) – Making a movie about Elizabeth Taylor takes courage. Casting wayward starlet Lindsay Lohan as the Hollywood screen legend was both daring and asking for trouble.


And indeed, trouble is what producers got during the shooting of Lifetime TV movie “Liz & Dick” – but they say the payoff made it all worthwhile.













“Let’s say that producing a movie with Lindsay Lohan is not for the faint of heart,” said executive producer Larry Thompson. “I turned 50 shades of white during production…But the risk was worth the rewards; the pain was worth the pleasure.”


“Liz & Dick,” which premieres on November 25, recounts the scandalous and tumultuous romance between Taylor and British actor Richard Burton in the 1960s and 70s. Lohan is one of the few people ever to have portrayed the diamond-loving, larger-than-life, two-time best actress Oscar winner on screen.


The idea was irresistible. Who better than Lohan, 26, a former child star herself, would know the pressures of having her every move scrutinized by the media, the allure of drink and drugs, and the thrills and risks of living life on the edge?


“I think Lindsay Lohan…literally knows no boundaries and that becomes dangerous and exciting. And she has the ability to bring to the screen and her performance that danger, that raw emotion,” Thompson told reporters ahead of the premiere.


“If you are going to make a movie about Taylor, you damn well want some great magic. And we felt that Lindsay Lohan could bring that.”


Some reviews for “Liz & Dick” have been savage. The Hollywood Reporter called Lohan “woeful as Taylor from start to finish” and the TV movie “an instant classic of unintentional hilarity.” Variety was kinder, calling Lohan “adequate” and the film “hammy” but “pretty good, all things considered.” Both noted casting Lohan was a sound publicity move.


Thompson however is proud of the 90-minute TV film. “I think people will see (New Zealand actor) Grant Bowler as Richard Burton just steals your heart, and Lindsay Lohan breaks it.”


PAGES OF ‘WHAT IFS’


After five years of legal troubles, numerous trips to jail, rehab, and courtrooms, the “Mean Girls” star was looking for a project that could re-establish the credentials that had once made her among the most promising young actresses in Hollywood.


But her past brought problems with insurance for the movie, shooting schedules and the personal setbacks Lohan faced during the making of the TV film earlier this year.


Thompson said the deal with Lohan included “pages and pages of ‘what if’ clauses. What if there is a car accident? What if there is a violation of probation and she would be incarcerated? She might be the most insured actress to ever walk on a soundstage.”


The clauses were needed. During shooting, Lohan was involved in a serious car crash in the California beach city of Santa Monica, and on a separate occasion she was rushed to the hospital suffering from what as described as “exhaustion and dehydration.”


And just as Taylor and Burton were hounded by (and sometimes courted) the media during their highly public extra-marital affair, Lohan and the production staff had the paparazzi to deal with.


“There were paparazzi following us around, hanging out of trees every day. And while we were making a movie about Elizabeth Taylor being followed by paparazzi, we had real paparazzi following our paparazzi following Elizabeth Taylor. So it was life imitating art, art imitating life,” said Thompson.


Thompson acknowledged that fans of Taylor, who died in 2011 at age 79 after eight marriages – two of them to Burton – will believe there is no actress who could possibly play her. Burton died in 1984 at the age of 58.


Yet Lifetime chose Lohan also in the hope she would bring a younger generation of her own fans to the movie.


“A lot of young people today think Liz Taylor is an old woman sitting in a wheelchair next to Michael Jackson, whereas our movie is about the young, vibrant, highest-paid movie star in the world at the height of her beauty and power,” Thompson said.


As for whether he would work again with Lohan despite the challenging shoot?


“Sure,” Thompson said.


(Reporting by Jill Serjeant; Editing by Christine Kearney and Lisa Shumaker)


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Those TV Ads for High Cholesterol and Erectile Dysfunction Probably Aren’t Going Away
















It has been almost two decades since pharmaceutical manufacturers decided that they might have better luck promoting their products if they bypassed doctors and took their messages straight to consumers. And although the Food and Drug Administration is keeping a wary eye on direct-to-consumer advertising, the practice now appears solidly entrenched. The United States and New Zealand are the only two countries among developed nations that permit direct-to-consumer advertising.


Direct-to-consumer pharmaceutical advertising, or DTC, was never against the law. But pharmaceutical manufacturers began targeting consumers in the 1980s and, in 1999, the FDA clarified the rules on DTC advertising to better protect consumers. Since then, the practice has exploded. According to a 2011 report issued by the Congressional Budget Office, DTC advertising totaled $ 4.7 billion in 2008—about one-quarter of pharmaceutical manufacturers’ promotional budgets.













This year, the FDA launched two new studies on the impact of DTC drug ads and also issued new instructions to manufacturers on how it will review the content of drug ads. However, other attempts to reign in DTC ads, such as through legislation, haven’t progressed very far.


“I think there are a lot of people who want us to pull back from DTC advertising. They think it’s gotten out of hand,” Francis B. Palumbo, professor and executive director of the University of Maryland School of Pharmacy Center on Drugs & Public Policy, told TakePart. But, he adds: “It’s kind of woven into the fabric of American culture now. To pull it back would be very difficult. It’s a question of what would happen if you pulled the plug.”


Some studies suggest that DTC ads aren’t so bad. The ads can educate people, help them start a conversation with their doctors, and even prompt someone to see a doctor when they otherwise might not have. Information contained in the ads may improve patient compliance regarding instructions on how to take a particular drug and how to spot side effects.  


But the ads have generated considerable controversy. Doctor groups tend to dislike the practice, Palumbo says, because consumers demand prescriptions for certain medications they’ve heard about on TV. Sometimes, doctors say,  their patients would benefit more and save money by taking a different medication than the one advertised on television.


RELATED: Beware Rogue Online Pharmacies, FDA Says


“Patients put more pressure on their doctors to prescribe a particular drug when they see it on TV,” Palumbo says.


Other healthcare experts have questioned whether DTC leads to higher drug costs. And, because many DTC ads are for newly approved medications, some critics say the ads expose consumers to unnecessary risks. For example, the drug Vioxx was heavily advertised and sold to millions of people but was later taken off the market because of serious health risks linked to its use.


Certain classes of medications advertised to consumers have triggered considerable controversy, such as advertisements for drugs to treat depression, Palumbo says. While it may be helpful for consumers to know there are treatments for depression, drug companies have been criticized for pitching atypical antipsychotics, a newer class of drugs, for the treatment of depression. Many atypical antipsychotics are costly and carry harsh side effects. Typically, such medications are only prescribed when other treatment options have been exhausted.


RELATED: Americans Struggling to Pay for Prescription Drugs


According to the Congressional Budget Office report, pharmaceutical manufacturers only promote a small set of specific drugs using DTC. The CBO looked at 366 brand-name drugs that were promoted to doctors and other healthcare professionals from 1999 to 2008. Of those drugs, only 73 were advertised directly to consumers. Drug companies spent an average of $ 71 million per drug for a two-year period of DTC advertising.


The CBO found that the average number of prescriptions for newly approved brand-name drugs with DTC advertising was nine times greater than the average number of prescriptions written for newly approved brand-name drugs that weren’t advertised. But pharmaceutical companies are selective about which products are advertised to consumers. They tend to focus on medications for common conditions that affect large numbers of people, like high cholesterol or seasonal allergies.


“When pharmaceutical companies advertise directly to the consumer their sales go up,” Palumbo says. “That’s why they do it. They garner huge sales.”


RELATED: The Most Expensive Prescription Drugs in the U.S.


The FDA is watching the DTC scene carefully. Earlier this year, the agency launched a study examining the impact of “corrective” direct-to-consumer advertising. This is a type of ad that the agency demands of pharmaceutical manufacturers when the company’s initial ad features false or misleading information. One of the best-known examples of a corrective ad was for the birth control pill Yaz. The agency is looking at how corrective ads impact consumer misperceptions about the drug. In other words, do the corrective ads reverse the false impression?


Another FDA study, announced in August, will examine whether consumers understand ads for drugs that have “composite scores.” These are drugs that are advertised for multiple symptoms, such as an allergy drug touted for sneezing, runny nose, watery eyes and wheezing. Such drugs are given a single composite score (encompassing the effectiveness scores for each particular symptom) that shows how effective the drug is compared to another drug. But, the FDA states: “Because most DTC prescription drug ads do not explicitly state that they used composite scores” consumers may not understand the drug’s actual efficacy.


Also this year, the FDA informed pharmaceutical companies that it wants to review DTC ads for new drugs and drugs with new indication before they appear before the public to make sure the ads include all pertinent risk information. The agency will have 45 days to conduct the review


“FDA is under a lot of criticism for that,” Palumbo notes. “FDA is always under-resourced, and the question is whether FDA will get back to the manufacturer in a timely manner. The manufacturers are spending millions of dollars putting out these ads. They want to run them.”


Question: Should FDA tighten the reins on DTC drug ads? Tell us what you think in the comments.



Shari Roan is an award-winning health writer based in Southern California. She is the author of three books on health and science subjects.


Medications/Drugs News Headlines – Yahoo! News



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Clinton heads to Mideast amid Gaza crisis

GAZA CITY, Gaza Strip (AP) — Efforts to end a week-old convulsion of Israeli-Palestinian violence drew in the world's top diplomats on Tuesday, with President Barack Obama dispatching his secretary of state to the region on an emergency mission and the U.N. chief appealing from Cairo for an immediate cease-fire.

Israel and Gaza's militant Hamas rulers have staked out tough, hard-to-bridge positions, and the gaps keep alive the threat of an Israeli ground invasion. On Tuesday, grieving Gazans were burying militants and civilians killed in ongoing Israeli airstrikes, and barrages of rockets from Gaza sent terrified Israelis scurrying to take cover.

From Egypt, U.N. chief Ban Ki-moon said he came to the region because of the "alarming situation."

"This must stop, immediate steps are needed to avoid further escalation, including a ground operation," Ban said. "Both sides must hold fire immediately ... Further escalation of the situation could put the entire region at risk."

U.S. Secretary of State Hillary Rodham Clinton departed for the Mideast on Tuesday from Cambodia, where she had accompanied Obama on a visit. Clinton is to meet with Israeli Prime Minister Benjamin Netanyahu in Jerusalem, Palestinian President Mahmoud Abbas in the West Bank and Egyptian leaders in Cairo, according to U.S. and Palestinian officials.

The U.S. considers Hamas, which has killed hundreds of Israelis in suicide and other attacks, to be a terror group and does not meet with its officials. Washington blames Hamas rocket fire for the latest eruption of violence and says Israel has the right to defend itself. At the same time, it has cautioned that a ground invasion could send casualties spiraling.

By Tuesday, 115 Palestinians, including 54 civilians, have been killed since Israel mounted an air onslaught that has so far included nearly 1,500 strikes. Some 840 people have been wounded, including 225 children, Gaza health officials said.

Three Israeli civilians have also been killed and dozens wounded since the fighting began last week, the numbers possibly kept down by a rocket-defense system Israel developed with U.S. funding. More than 1,000 rockets have been fired at Israel this week, the military said.

Netanyahu said Tuesday that Israel wouldn't balk at a broader military operation.

"I prefer a diplomatic solution," Netanyahu said in a statement after meeting with Germany's foreign minister, Guido Westerwelle, who is also in the region trying to advance peace efforts. "But if the fire continues, we will be forced to take broader measures and will not hesitate to do so."

Successive Israeli governments have struggled to come up with an effective policy toward Hamas.

Neither Israel's economic blockade of the territory of 1.6 million people nor bruising military strikes have cowed Gaza's Islamists, weakened their grip on the coastal strip or fire rockets at the Jewish state.

An Israeli ground invasion would risk Israeli troop losses, and could send the number of Palestinian civilian casualties ballooning — a toll Israel could be reluctant to risk just four years after its last invasion drew allegations of war crimes.

Still, with Israeli elections just two months away, polls show Israeli public sentiment has lined up staunchly behind the Netanyahu government's offensive.

Turkey's foreign minister and a delegation of Arab League foreign ministers headed to Gaza on Tuesday on a separate truce mission. Before setting off, Foreign Minister Ahmet Davutoglu signaled Turkey was in contact with Israel bout a truce — an important development given the two countries' chilly ties.

"We would be involved in all kinds of efforts if it amounted to saving the life of a single brother from Gaza," Davutoglu said. "We are determined to keep all direct or indirect channels (of dialogue) open."

Turkey's once-close ties with Israel frayed badly over the high civilian toll during Israel's 2009 war in Gaza.

With tens of thousands of Israeli soldiers dispatched to the Gaza border, awaiting a possible order to invade, the truce missions were all the more urgent.

Egypt, the traditional mediator between Israel and the Arab world, has been at the center of recent diplomatic efforts.

Israel demands an end to rocket fire from Gaza and a halt to weapons smuggling into Gaza through tunnels under the border with Egypt. It also wants international guarantees that Hamas will not rearm or use Egypt's Sinai region, which abuts both Gaza and southern Israel, to attack Israelis.

Hamas wants Israel to halt all attacks on Gaza and lift tight restrictions on trade and movement to and from the territory imposed after Hamas seized Gaza by force in 2007. Israel has rejected such demands in the past.

Resurgent rocket fire set off the Israeli offensive, launched with the assassination of the Hamas military chief and followed by hundreds of airstrikes on militant rocket launchers and weapons stores.

The onslaught turned deadlier over the weekend, as airstrikes began targeting the homes of suspected Hamas activists, leading to a spike in civilian casualties. Israel sent warnings in some cases, witnesses said, but in other instances missiles hit suddenly, burying residents under the rubble of their homes.

Hamas is deeply rooted in densely populated Gaza, and the movement's activists live in the midst of ordinary Gazans. Israel says militants are using civilians as human shields, both for their own safety and to launch rocket strikes from residential neighborhoods.

In one case, a senior member of the military wing of Islamic Jihad rented a small apartment in a 15-story high-rise of offices and news outlets. The militant, Ramez Harb, was killed Monday in a rocket strike that damaged the building.

One journalist said he and others were furious that Harb had apparently used their building as a hideout, putting others at risk. He spoke on condition of anonymity because he feared repercussions from Gaza militants.

Early Tuesday, Israeli aircraft targeted another Hamas symbol of power, the headquarters of a bank senior Hamas officials set up to sidestep international sanctions on the militant group's rule. After Hamas overran Gaza, foreign lenders stopped doing business with its militant-led government, afraid of running afoul of international terror financing laws.

The inside of the bank was destroyed and a building supply business in the basement was damaged.

"I'm not involved in politics," said the business owner, Suleiman Tawil. "I'm a businessman. But the more the Israelis pressure us, the more we will support Hamas."

Israel and Gaza's militants have a long history of fighting, but the dynamics have changed radically since they last warred four years ago. Though their hardware is no match for the Israeli military, militants have upgraded their capabilities with weapons smuggled in from Iran and Libya, Israeli officials claim.

Only a few years ago, tens of thousands of Israelis were within rocket range. Today those numbers have swollen to 3.5 million, as the militants' improved weapons reached Tel Aviv and Jerusalem for the first time this past week.

Hamas, a branch of the region-wide Muslim Brotherhood, is also negotiating from a stronger position than four years ago. At that time, Hamas was internationally isolated; now, the Muslim Brotherhood is in power in Egypt and Tunisia, and Hamas is also getting political support from Qatar and Turkey.

At home, too, the military offensive has shored up Hamas at a time when it was riven by internal divisions over its direction and the new Egyptian government's refusal to lift the blockade it imposed along with Israel after Hamas seized the territory.

This newfound backing contrasts radically with the loss of stature the Western-backed Palestinian President Mahmoud Abbas has endured as Palestinians lose faith in his ability to bring them a state through negotiations with Israel.

____

Teibel reported from Jerusalem. With contributions from Ibrahim Barzak in Gaza City and Suzan Fraser in Ankara, Turkey.

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