Texas Instruments cuts 1,700 jobs, winds down tablet chips
















NEW YORK/SAN FRANCISCO (Reuters) – Texas Instruments is eliminating 1,700 jobs, as it winds down its mobile processor business to focus on chips for more profitable markets like cars and home appliances.


Texas Instruments said in September it would halt costly investments in the increasingly competitive smartphone and tablet chip business, leading Wall Street to speculate that part of the company’s processor unit, called OMAP, could be sold.













The layoffs are equivalent to nearly 5 percent of the Austin, Texas-based company’s global workforce.


“A sale would have been better than a restructuring but a restructuring is certainly better than nothing,” Sanford Bernstein analyst Stacy Rasgon said.


TI has been under pressure in mobile processors, where it has lost ground to rival Qualcomm Inc. Leading smartphone makers Apple Inc and Samsung Electronics Co Ltd have been developing their own chips instead of buying them from suppliers like TI.


Instead of competing in phones and tablets, TI wants to sell its OMAP processors in markets that require less investment, like industrial clients like carmakers.


TI is expected to continue selling existing tablet and phone processors for products like Amazon.Com Inc‘s Kindle tablets for as long as demand remains, but stop developing new chips.


“This year, the Kindle runs on the OMAP 4 and next year’s Kindle is slated, we believe, for OMAP 5. We believe that program is well along to completion and do not expect that the termination of OMAP will disrupt those plans,” said Longbow Research analyst JoAnne Feeney.


Amazon had reportedly been in talks to buy the mobile part of OMAP.


TI said it expects to take charges of about $ 325 million related to the job cuts and other cost reduction measures, most of which will be accounted for in the current quarter. Its previously announced financial targets for the fourth quarter do not include these costs, TI said.


The company, which has 35,000 employees around the world, expects annualized savings of about $ 450 million by the end of 2013 from the action.


TI shares rose to $ 29 in after-hours trading after closing at $ 28.76, down 2 percent on Nasdaq.


(Reporting By Sinead Carew in New York and Noel Randewich in San Francisco; editing by Carol Bishopric)


Tech News Headlines – Yahoo! News



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“Twilight Saga” ends with movie love letter to fans
















LOS ANGELES (Reuters) – “Twilight” fans bid an emotional farewell this week to Bella, Edward and Jacob in “Breaking Dawn-Part 2,” the romantic book and movie franchise that ignited a pop culture infatuation with blood-sucking vampires and werewolves.


The tumultuous love triangle between human girl Bella Swan, vampire Edward Cullen and werewolf Jacob Black, that has gripped avid fans known as “Twi-hards” for seven years, comes to a tantalizing end as “Breaking Dawn-Part 2″ hits movie theaters around the world.













The “Twilight” film franchise, based on a series of novels by Stephenie Meyer, rocketed the three main stars, Kristen Stewart (Bella), Robert Pattinson (Edward) and Taylor Lautner (Jacob), into the spotlight and the first four films have grossed more than $ 2.5 billion at the worldwide box office.


For director Bill Condon, who shot both parts of “Breaking Dawn” together and split into two movies post-production, the fifth and final film was all about the fans – who get a surprise twist to the ending.


“The real challenge was to make sure it was a satisfying climax,” Condon told reporters. “The film opens with an overture of all the main scenes from all five movies, and at the end, I…brought (it) back to the spirit of the old movies.”


The movie pays homage to the angst-ridden teenage romance between Bella and Edward that was underscored by the off-screen real-life romance between Stewart, 22, and Pattinson, 26.


“Breaking Dawn-Part 2″ shifts the action from a love story to a family story, as the Cullen clan recruit their extended vampire family to protect Bella and Edward’s daughter Renesmee from an ancient vampire coven.


“I think it’s very sweet, especially the ending of it, I think it’s very close to the book as well. It seems to be that it’s really made for the fans,” Pattinson told Reuters.


GOING OFF BOOK


While the past four films have stayed true to the books, author Meyer and screenwriter Melissa Rosenberg came up with a plot twist that adds a major scene that may surprise movie-goers.


“(The action) is off screen in the novel because we only see what Bella sees, and this was just a way of making visual what some of the other characters might have seen,” Meyer told reporters.


“It does feel very surprising. There’s something new to see but to me it doesn’t seem like it’s going hugely off the page,” she added.


While the fourth film saw Bella’s human life draw to a conclusion when she died giving birth to a human-vampire hybrid baby with new husband Edward, “Breaking Dawn-Part 2,” sees Bella as a mother and a newly-transformed vampire.


“The coolest thing about vampire Bella is that I got to play her as a human for so long, and the special parts of each vampire are always informed by the great things that they were as a human and so I got to walk in those shoes,” Stewart told Reuters.


“Everything made total sense to me. I waited for so long (to play a vampire), once I finally got it, it was so comfortable, I couldn’t wait,” the actress added.


“The Twilight Saga,” first published in 2005, kicked off a wave of vampire or supernatural-themes books, films and TV shows including HBO’s “True Blood,” the CW TV network’s “The Vampire Diaries” and Richelle Mead’s “Vampire Academy” series of young adult novels.


As the sun sets on the franchise Meyer brought to life, the author said that while she didn’t rule out the possibility of finding more stories in the vampire-werewolf universe, she had closed the chapter on the Cullens.


“I don’t know if I’ll ever get back to these (stories). Someday I’ll write down what was going to happen next. It’s sad knowing I don’t have another party with the kids again, I really hope I have a chance to at least see my friends again,” she told Reuters.


(Reporting by Piya Sinha-Roy, editing by Jill Serjeant and Marguerita Choy)


Movies News Headlines – Yahoo! News



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A Good Reason — Pregnancy, Your Dog, Money, Anything — is Key to Quitting Smoking
















Nov. 15 marks this year’s Great American Smokeout, when organizations across the country encourage smokers to quit the habit. Yahoo asked former smokers to offer to advice to those trying to stop smoking.


FIRST PERSON | I remember when I quit smoking one weekend. It was a Saturday night and I was pre-gaming with some friends before going out. Someone suggested taking a smoke break, and I went along to be with the crowd. Last thing I remember was having a great time, surrounded by secondhand smoke from cigarettes and Black & Milds. Then I woke up the next morning with a fresh pack of Newports in my purse. There was a few missing from the pack. I wasn’t sure who bought these cigarettes for me, but the taste in my mouth told me who smoked them. That was the first time I realized that I’d have to change my friends if I was going to change my lifestyle.













However, that didn’t happen until over a year later.


Make the choice and follow through


The moment I found out I was pregnant, I knew my cigarette days had to be over. The people that I partied with were not of the “best friends forever” variety, so it was not an impossible challenge to stop going out with them.


Being pregnant turned me off to the smell of smoke, anyway. It was after I gave birth that I had to really stick to my guns about quitting. I haven’t smoked in more than two years, but I’d be lying if I said that I don’t crave a cigarette every now and then. I doubt those cravings will go away completely, but my child is my motivation to stay away for good.


You don’t have to have a child to quit smoking. The most important thing to keep in mind is the reason why you need to quit. It can be for your health, for your dog, to save money — anything. Anything that you feel passionate about, keep it in your mind because, without a reason, you’re not going to make it. You may fail, and that’s OK. But never give up.


It may be tough to make changes to your life or change your friends, but that’s a necessary change to make if you want to succeed. At least keep yourself away from temptation until you having a good handle on your life as an ex-smoker.


The easy thing about quitting is after you stomp out your cigarette, you quit. It’s up to you if you want to light another one up.


Parenting/Kids News Headlines – Yahoo! News



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Sources: BP to pay record fine for Gulf Coast disaster

HOUSTON/WASHINGTON (Reuters) - BP Plc is expected to pay a record U.S. criminal penalty and plead guilty to criminal misconduct in the 2010 Deepwater Horizon disaster through a plea deal reached with the Department of Justice that may be announced as soon as Thursday, according to sources familiar with discussions.


Three sources, who spoke to Reuters on condition of anonymity, said BP would plead guilty in exchange for a waiver of future prosecution on the charges.


BP confirmed it was in "advanced discussions" with the Department of Justice (DoJ) and the Securities & Exchange Commission (SEC).


The talks were about "proposed resolutions of all U.S. federal government criminal and SEC claims against BP in connection with the Deepwater Horizon incident," it said in a statement on Thursday, but added that no final agreements had been reached.


The discussion do not cover federal civil claims, both BP and the sources said.


London-based oil giant BP has been locked in months-long negotiations with the U.S. government and Gulf Coast states to settle billions of dollars of potential civil and criminal liability claims resulting from the April 20, 2010, explosion aboard the Deepwater Horizon rig.


The sources did not disclose the amount of BP's payment, but one said it would be the largest criminal penalty in U.S. history. That record is now held by Pfizer Inc, which paid a $1.3 billion fine in 2009 for marketing fraud related to its Bextra pain medicine.


The DoJ declined to comment.


The deal could resolve a significant share of the liability that BP faces after the explosion killed 11 workers and fouled the shorelines of four Gulf Coast states in the worst offshore spill in U.S. history. BP, which saw its market value plummet and replaced its CEO in the aftermath of the spill, still faces economic and environmental damage claims sought by U.S. Gulf Coast states and other private plaintiffs.


The fine would far outstrip BP's last major settlement with the DoJ in 2007, when it payed about $373 million to resolve three separate probes into a deadly 2005 Texas refinery explosion, an Alaska oil pipeline leak and fraud for conspiring to corner the U.S. propane market.


The massive settlement, which comes a week after the U.S. presidential election, could ignite a debate in Congress about how funds would be shared with Gulf Coast states, depending on how the deal is structured. Congress passed a law last year that would earmark 80 percent of BP penalties paid under the Clean Water Act to the spill-hit states of Louisiana, Mississippi, Alabama, Florida and Texas.


POTENTIAL LIABILITY


In an August filing, the DoJ said "reckless management" of the Macondo well "constituted gross negligence and willful misconduct" which it intended to prove at a civil trial set to begin in New Orleans in February 2013. The U.S. government has not yet filed any criminal charges in the case.


Given that the deal will not resolve any civil charges brought by the Justice Department, it is also unclear how large a financial penalty BP might pay to resolve the charges, or other punishments that BP might face.


Negligence is a central issue to BP's potential liability. A gross negligence finding could nearly quadruple the civil damages owed by BP under the Clean Water Act to $21 billion in a straight-line calculation.


Still unresolved is potential liability faced by Swiss-based Transocean Ltd, owner of the Deepwater Horizon vessel, and Halliburton Co, which provided cementing work on the well that U.S. investigators say was flawed. Both companies were not immediately available for comment.


According to the Justice Department, errors made by BP and Transocean in deciphering a pressure test of the Macondo well are a clear indication of gross negligence.


"That such a simple, yet fundamental and safety-critical test could have been so stunningly, blindingly botched in so many ways, by so many people, demonstrates gross negligence," the government said in its August filing.


Transocean in September disclosed it is in discussions with the Justice Department to pay $1.5 billion to resolve civil and criminal claims.


The mile-deep Macondo well spewed 4.9 million barrels of oil into the Gulf of Mexico over a period of 87 days. The torrent fouled shorelines from Texas to Florida and eclipsed in severity the 1989 Exxon Valdez spill in Alaska.


BP has already announced an uncapped class-action settlement with private plaintiffs that the company estimates will cost $7.8 billion to resolve litigation brought by over 100,000 individuals and businesses claiming economic and medical damages from the spill.


(Additional reporting by Andrew Callus in London; Editing by Edward Tobin and David Stamp)


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Beating tax cheats key to Italy’s recovery plan
















ROME (AP) — Good plumbers may be worth their weight in gold, but when one was spotted zipping around in a bright red Ferrari, Italian tax police were fast on his trail.


Stamping out entrenched tax evasion is crucial to Premier Mario Monti‘s quest to keep Italy from succumbing to the European debt crisis, and it is critical to fellow eurozone members in more dire straits, such as Greece and Spain — which are also notorious for making cheating the taxman a way of life.













Indeed, Greece’s international rescue creditors have been pressing Greece for two years to reform its ailing tax system, citing poor collection as a key factor keeping the country mired in crisis. In Spain, where tax fraud is rampant, as much as €90 billion ($ 150 billion) is lost each year to tax fraud — the equivalent of the country’s national debt, according to Spain’s main tax inspectors union.


To succeed in Italy, authorities will have to catch the legions of self-employed and small business owners who brazenly lie about their earnings, like the plumber in the eastern town of Pescara, who socked away undeclared income in 30 bank accounts, or a successful pastry shop owner in Calabria, who on his tax return claimed he was earning next to crumbs.


And those are the less sophisticated schemers.


Tax police officials say that wealthy Italians, their companies and foreigners who make their money in Italy are increasingly trying to avoid taxes by using such strategies as falsely declaring that their base of operations or residence is abroad.


Another daunting challenge is the so-called “submerged” economy, a term embracing Italians who declare only a fraction or nothing at all of their earnings — and dentists, lawyers, doctors and other big-earning professionals are frequently among the worst offenders.


Tax evasion of all types in Italy totals about euros 240 billion ($ 300 billion), or 15 percent of the country’s gross domestic product of €1.6 trillion ($ 2 trillion), tax police estimate. Winning the war on tax cheats could therefore more than wipe out the country’s budget deficit, which is expected to increase to euros 42 billion ($ 53 billion), or 2.6 percent of GDP this year. That would start knocking away at the nation’s colossal public debt of €2 trillion ($ 2.5 trillion), or 125 percent of GDP.


But “big international frauds are up,” lamented Lt. Col. Gianluca Campana, in charge of the income tax unit revenue protection office at the Guardia di Finanza, Italy’s financial police corps which reports to the Economy Ministry.


The entrenched practice by many cafes, eateries, hair dressers and similar small business of neglecting to give customers mandatory cash register receipts commonly grabs the attention in crackdowns on tax evasion in Italy.


But, cautioned Campana, “one false (big business) invoice can equal no cash register receipts for coffees for two months.”


Over all of 2011, the total of non-declared income discovered by tax police amounted to some €50 billion ($ 65 billion), of which some 20 percent was due to international tax evasion, he said. By comparison, in the first nine months of this year, tax police discovered some €40 billion in undeclared income, with 30 percent of that blamed on international tax evasion, Campana said.


With the economic crisis shrinking bottom lines, and Italy increasingly on the hunt for big-time evasion, especially by big businesses, “there is a tendency to move capital abroad, using maneuvers apparently legal but which really are not,” Campana said. A classic technique consists of declaring one’s formal residence abroad in tax havens like Monte Carlo. Also common are companies that clearly have their business base in Italy but claim it is abroad in countries with far lower tax brackets.


Campana is armed with three degrees, including a masters in tax law from Milan’s Bocconi University, the prestigious economics institute formerly headed by Monti. He brings skills to this specialized police corps that are as finely tuned as sharp-shooting.


“We are going after the big cases (of evasion) in order to rake in more money,” Campana said.


The Ferrari-driving plumber hid some €2 million ($ 2.6 million) of his income over several years by giving his customers invoices — for jobs ranging from fixing leaks to installing new bathrooms — for the actual cost of his work, but kept a second, false registry of much lower figures for tax purposes, said Pescara tax police Col. Mauro Odorisio.


Armed with a 2008 law, authorities confiscated assets belonging to the plumber equivalent to the approximately €1 million ($ 1.3 million) they contend he owed in taxes, Odorisio said.


With Ferraris in red or yellow, and snazzy Porsches parked inside, Guardia di Finanza garages practically resemble luxury car dealerships.


The cars get sold to help recoup unpaid taxes and interest.


Overall, tax revenues in Italy were up by 4.1 percent, says the Economy Ministry, when comparing figures from the first eight months of 2012 with the same period in 2011, but much of that was due to new taxes, and not necessarily a revolution in citizens’ consciences about tax obligations.


Monti’s recipe relies heavily on taxes that are nearly impossible to avoid, such as sales tax. He also revived a property tax that his populist predecessor, Premier Silvio Berlusconi, had abolished in a promise to voters.


The ministry’s report last month noted that the property tax figured prominently in the “tendency toward growth” in tax revenues. But sales tax revenue dropped slightly despite higher sales tax rates, indicating that consumers were feeling the pinch of the stagnant economy.


The heavier fiscal burden seems to have driven some honest citizens to rebel against the engrained culture of tax evasion.


The number of phone calls from the public to the tax police’s hotline to report stores, restaurants and other businesses that didn’t give customers sales receipts has almost doubled in the first nine months of this year, compared with the same period in 2011.


It’s apparently dawning on Italians that shirking taxes in the end only costs them, in terms of ever-higher levies and cutbacks in public services.


Citizens now increasingly understand that “the lack of revenue over time caused by tax evaders forced the government to stiffen the tax burden on categories where you can’t evade taxes,” Campana said, referring to workers whose taxes are deducted from paychecks. Another area where evasion is close to impossible is real estate ownership.


Odorisio noted the crackdown included extending the statute of limitations on tax evasion from six to eight years and establishing prison as a penalty for big-time evasion.


Other weapons include a measure promoted by the Monti government that limits cash payments to no more than €1,000. Paying by credit card or personal check is a relatively new habit for Italians, who are used to carrying wads of cash in their pockets, even for big-ticket items like home renovations or vacations.


Past governments in Italy sometimes resorted to tax amnesties to try to boost revenues. But critics, contending some Italians counted on such a possibility, described that strategy as only perpetuating the tax cheat culture.


Spain hasn’t had much success with its own tax amnesty introduced by the conservative government in March. That measure, expiring soon, allows undeclared assets or those hidden in tax havens to be repatriated by paying a 10 percent tax without criminal penalty. The amnesty is estimated to recuperate far less than the expected €2.5 billion ($ 3.25 billion).


Greece saw demands for tax system reform from international rescue creditors added on to conditions for future rescue loan payments, as Greek authorities acknowledged that a high-profile campaign to crack down on major tax cheats has produced disappointing results.


The cash-strapped government over the last 10 months recovered just €19 million ($ 25 million) of the €13 billion ($ 17 billion) of arrears on the list. A prominent Greek magazine publisher recently tapped anger over rich tax evaders by publishing a list of people allegedly holding Swiss bank accounts. He was acquitted this month of breaching privacy laws.


Meanwhile, Italian tax police are chasing after cheats who have shown some of the most chutzpah about not paying their fair share of taxes, like the Padua woman who advertised on the Internet that she had a couple of “cash-only” bed and breakfast rooms to let.


Tax police discovered the lodgings are part of an apartment in public housing she was given after falsely declaring she was indigent on her annual tax forms.


____


AP reporters Derek Gatopoulos in Athens and Ciaran Giles in Madrid contributed to this report.


Europe News Headlines – Yahoo! News



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Microsoft and Google financials could surface at trial
















(Reuters) – Microsoft and Google‘s Motorola Mobility unit squared off on Tuesday at a trial with strategic implications for the smartphone patent wars and which could reveal financial information the two companies usually keep under wraps.


The proceeding in a Seattle federal court will determine how much of a royalty Microsoft Corp should pay Google Inc for a license to some of Motorola‘s patents. Google bought Motorola for $ 12.5 billion, partly for its library of communications patents.













If U.S. District Judge James Robart decides Google deserves only a small royalty, then its Motorola patents would be a weaker bargaining chip for Google to negotiate licensing deals with rivals.


Apple Inc and Microsoft have been litigating in courts around the world against Google and partners like Samsung Electronics Co Ltd, which use the Android operating system on their mobile devices.


Apple contends that Android is basically a copy of its iOS smartphone software, and Microsoft holds patents that it contends cover a number of Android features.


Motorola had sought up to $ 4 billion a year for its wireless and video patents, while Microsoft argues its rival deserves just over $ 1 million a year. A federal judge in Wisconsin last week threw out a similar case brought by Apple against Google just before trial.


In court on Tuesday Microsoft called Jon DeVaan, a veteran software manager in the Windows division, as its first witness. He said Motorola‘s wireless and video patents at issue covered only a small part of the overall Windows architecture.


During the run-up to trial in Seattle, both Microsoft and Google asked Robart to keep secret a range of financial details about the two companies, including licensing deals and sales revenue projections. Google requested that Robart clear the courtroom when witnesses discuss those details.


However, in an order on Monday, Robart rejected that request. The public will not be able to view the documents describing patent deals or company sales during trial, Robart ruled, but testimony will be in open court.


“If a witness discloses pertinent terms, rates or payments, such information will necessarily be made public,” the judge wrote.


Additionally, any documents the judge relies on for his final opinion will be disclosed, Robart wrote on Monday.


Before trial began on Tuesday, Robart said in court that he wanted to take the most “expansive” interpretation of the public’s right to know. Several outside companies besides Microsoft and Motorola, like Research in Motion Inc, have also asked him to keep secret their royalty deals.


Robart said he would consider a request to refer to those third party companies by code names, known only to the lawyers and the judge.


The case in U.S. District Court, Western District of Washington is Microsoft Corp. vs. Motorola Inc., 10-cv-1823.


(Reporting By Bill Rigby in Seattle and Dan Levine in San Francisco; editing by Jim Marshall and Carol Bishopric)


Wireless News Headlines – Yahoo! News



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Anne Hathaway reveals oatmeal paste diet for ‘Les Miserables’
















LOS ANGELES (Reuters) – Hollywood starlet Anne Hathaway credits a strict diet of dried oatmeal paste for helping her shed some 25 pounds (11 kg) for her role in the forthcoming big screen musical “Les Miserables.”


“I had to be obsessive about it – the idea was to look near death,” Hathaway told Vogue about preparing for her role as the consumptive prostitute Fantine in the musical version of Victor Hugo‘s classic 19th century French novel.













Hathaway, 30, told the December edition of the magazine, that she first lost 10 pounds (5 kg) to begin filming and then later dropped another 15 pounds (7 kg) by eating nothing but two thin pieces of oatmeal paste a day.


“Looking back on the whole experience – and I don’t judge it in any way – it was definitely a little nuts,” said “The Dark Knight Rises” actress. “It was definitely a break with reality, but I think that’s who Fantine is anyway.”


Extreme body changes have become part of Hollywood lore, even factoring into the marketing of films. Natalie Portman received much publicity for dropping some 20 pounds (9 kg) for her Oscar-winning role as a ballerina in 2010′s “Black Swan.”


Jennifer Lawrence, who plays the famished star of the life-or-death thriller “The Hunger Games,” made waves last week vowing never to diet for a role.


Hathaway said it was a rocky transition back into everyday life after filming.


“I was in such a state of deprivation – physical and emotional,” she said. “When I got home, I couldn’t react to the chaos of the world without being overwhelmed. It took me weeks till I felt like myself again.”


Directed by Tom Hooper (“The King’s Speech”), “Les Miserables” is scheduled to be released on December 25 in the United States and is seen as a strong contender for Oscar nominations. The film version of the stage musical also stars Hugh Jackman and Russell Crowe.


(Reporting By Eric Kelsey; Editing by Jill Serjeant and Mohammad Zargham)


Music News Headlines – Yahoo! News



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New Hope For ‘Man on Fire Syndrome’
















Pamela Costa has never known a day without agonizing pain in her legs and feet.


At age 11, the Seattle native was diagnosed with inherited erythromelalgia, a genetic condition that causes such severe pain and redness some call it “Man on Fire Syndrome.”













“Think of the feeling that you get when you come in from the cold and your hands and feet are rewarming too fast,” said Costa, 47. “I have that feeling all of the time.”


Inherited erythromelalgia is a disease of small nerves and blood vessels that causes severe pain in response to heat, pressure, exertion or stress.


“These people feel excruciating, scalding pain while putting on shoes or putting on a sweater,” said Dr. Stephen Waxman, a neuroscientist at Yale University and the West Haven Veterans Affairs Hospital. “They will keep their feet on ice to the point of getting gangrene, just to relieve the sensation.”


When Costa was growing up, playing outside would trigger the unbearable burning sensation.


“I used to come in from recess and just hold my hands on the cool metal of my school desk,” said Costa, who has more than two dozen relatives with the same affliction. “I have had cousins suffer devastating injuries from over-cooling themselves.”


Although the disease is rare, researchers are searching for clues to its cause with hopes of uncovering treatments for chronic pain of all kinds. The story starts at the molecular level within tiny nerves that conduct pain signals.


An Overactive Channel Protein


Pain comes in different forms, depending on the type of nerve that senses it. And for chronic pain patients, the pain is not quick and specific, but instead slow and sharp.


This slow pain is transmitted from the limbs and body to the brain along small nerves in the spinal cord called C-fibers. Messages move along these nerve fibers due to the action of special proteins in their membranes called channels. One specific type of channel is the Nav1.7 sodium channel, which is present in great numbers in the C-fibers of the spinal cord.


Work by Waxman and others has shown that patients with inherited erythromelalgia have a defect in their Nav1.7 channels that allows too many sodium ions to enter the C-fibers, causing an increase in the sensitivity of the nerves.


The specific atomic structure of the Nav1.7 channel has been modeled by Waxman’s lab, and the results are detailed in the current issue of Nature Communications. Armed with this new model of the Nav1.7 channel, the lab has been able to show why some patients with inherited erythromelalgia respond well to an anti-epileptic drug called Carbamazepine.


Furthermore, in studying the channel structure in many different people, Waxman and colleagues have found variations in the channel from person to person. These variations may cause some people to be more likely to experience chronic pain than others.


A New Drug Target


Patients with a completely defective Nav1.7 suffer from the opposite condition, known as congenital indifference to pain. These people do not experience pain at all, with case reports of being able to walk on hot coals without pain.


As the role of Nav1.7 in the mechanism for pain sensation becomes clearer, biotechnology and pharmaceutical companies will likely take notice, according to Waxman.


“I anticipate a race to develop Nav1.7 specific blockers,” he said.


Current drug therapies for pain include medicines like morphine, as well as aspirin and ibuprofen. While all of these decrease the sensation of pain, they also interact with other tissues such as the brain, heart and stomach, causing side effects.


Nav1.7 does not appear to be present in large quantities outside of the C-fibers of the spinal cord. As such, new drugs targeting this protein could herald a new class of pain treatments with many fewer side effects than our current drugs for pain.


Costa said she hopes to see a day where such a medicine would be available to her, providing her with full relief for the first time in her life.


Also Read
Medications/Drugs News Headlines – Yahoo! News



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Why an election that brought in the status quo will bring change

RT @rickklein: Why a status quo election will bring change | Power Players #TopLine - @YahooNews http://t.co/ekA3hnTa
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General investigated for emails to Petraeus friend
















PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.


Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.













Panetta said that he ordered a Pentagon investigation of Allen on Monday.


A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.


Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.


Petraeus resigned as CIA director on Friday.


Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.


The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.


The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.


“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.


Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.


The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.


Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.


In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.


Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.


NATO officials had no comment about the delay in Allen’s appointment.


“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”


Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.


___


Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.


Asia News Headlines – Yahoo! News



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